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Lecturer(s)
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Kanďár Roman, prof. Mgr. Ph.D.
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Course content
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Introduction to xenobiochemistry, xenobiotics. Biotransformation of xenobiotics, relationship between structure and metabolism of xenobiotics. Phase I of biotransformation. Hydrolytic and oxidoreduction reactions. Microsomal monooxygenases dependent on cytochrome P450. Flavin monooxygenases and other enzymes catalysing the oxidation of xenobiotics. Phase II of biotransformation - conjugation reactions. Phase III of biotransformation - cellular transport of xenobiotics. Regulation of biotransformation enzymes, factors influencing biotransformation of xenobiotics. Induction and inhibition of biotransformation enzymes. Biotransformation of polycyclic aromatic hydrocarbons, AhR receptors. Genetic polymorphism. Drug interactions and resistance. Extrahepatic biotransformation of xenobiotics.
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Learning activities and teaching methods
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Monologic (reading, lecture, briefing)
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Learning outcomes
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Students will acquire basic knowledge in xenobiochemistry.
After completing the course, the student is able to orientate himself in the field of xenobiochemistry.
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Prerequisites
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Not specified
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Assessment methods and criteria
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Oral examination
The exam is oral. The basic form of the exam is a discussion on selected topics. The degree of acquired knowledge is examined.
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Recommended literature
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Skálová, Lenka. Metabolismus léčiv a jiných xenobiotik. Praha: Karolinum, 2011. ISBN 978-80-246-1917-0.
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