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Lecturer(s)
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Štěpánková Šárka, Mgr. Ph.D.
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Čegan Alexander, prof. Ing. CSc.
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Course content
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Aminoacids, peptides and proteins - chirality, function, importance, division according to structure. Saccharides - chirality, nomenclature, function and importance. Glycosidic bond. Derivates of saccharides. Lipids - structure, importance and division. Simple, combined and polar lipids. Phospholipids. Vitamins - structure, function, presence, importance. Hormones ? structure, function and importance. Nucleosides, nucleotides, nucleic acids - structure and importance. Genetic code and mutations. Enzymes - classification, nomenclature and biochemical importance, active and allosteric site. Kinetics of enzymatic reactions, substrate and function specificity. Enzyme inhibition. Respiration chain and oxidative phosphorylation. Chemiosmotic theory of ATP synthesis. Photosynthesis. Citric acid cycle, glyoxylate cycle, principle, importance. Degradation of pyruvate. Anaplerotic reactions. Glycolysis, fermentation, pentose phosphate pathway. Metabolism of fructose and galactose. Function of carnitine, beta-oxidation and modification for odd-numbered chain and unsaturated fatty acids. PropionylCoA. Proteins - degradation. Transamination, aldol degradation and decarboxylation. Degradation of carbon chains. Ammonia detoxication in animals. Ornithine cycle. Nucleotide degradation. Gluconeogenesis, glyconeogenesis. Biosynthesis of aminoacids, lipids and nucleotides.
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Learning activities and teaching methods
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Monologic (reading, lecture, briefing)
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Learning outcomes
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According the subject, students will be acquainted with a basic knowledges concerning biochemistry of living subjects with accent on the catabolic and anabolic processes. The course of biochemical processes is described on molecular level and documentated through chemical equations with enzyme catalysis.
According the subject, student will get a complex knowledges about course of basic metabolic processes of living subjects. He is able to solve a problems of enzymatic catalysis of biochemical equations and experimentaly follow the course of main different biochemical equations.
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Prerequisites
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not specified
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Assessment methods and criteria
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Oral examination, Written examination
Presence at seminar lessons is required. written test (success rate 50 % at least) oral exam (2 exam questions)
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Recommended literature
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MATHEWS CH. K., van HOLDE K. E., AHERN K. G. Biochemistry , Addison Wesley Longman Inc., San Francisco USA, 2000.
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Štern P. a kol. Obecná a klinická biochemie pro bakalářské obory studia, Nakladatelství Karolinum 2005..
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Vodrážka Z. Biochemie 1 - 3, Academia Praha 1992.
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Voet D., Voetová J.G. Biochemie, Victoria publishing Praha 1994.
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