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Lecturer(s)
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Kanďár Roman, prof. Mgr. Ph.D.
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Course content
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Introduction to pathobiochemistry, metabolic pathways Congenital metabolic disorders, examples of congenital metabolic disorders, enzymopathies: classification, origin, phenotypic manifestation, biochemical screening and diagnosis of congenital metabolic diseases, prenatal and neonatal screening Pathobiochemistry of carbohydrates, disorders of carbohydrate metabolism, disorders of fructose and galactose metabolism, glycogenesis, regulation of blood glucose and its disorders, mucopolysaccharidoses, glycoproteins and glycosylation: disorders, diabetes mellitus: molecular basis of diabetes, metabolic syndrome Pathobiochemistry of lipids, lipoproteins: structure, metabolism, dyslipoproteinemia, lipidoses, atherosclerosis Pathobiochemistry of proteins and amino acids, aminoacidopathy: phenylketonuria, MSUD, homocystinuria, ammonia production and metabolism: ornithine cycle disorders, intracellular protein degradation: disorders Pathobiochemistry of purines and pyrimidines, hyperuricemia, gout, orotaciduria Pathobiochemistry of porphyrins, porphyria and hemoglobinopathy Pathobiochemical changes in different types of icterus Pathobiochemistry of blood clotting, bleeding Pathobiochemistry of selected neurodegenerative diseases (Parkinson's disease, multiple sclerosis, Alzheimer's disease, Wilson's disease, myasthenia gravis) Mitochondrial diseases Hormone pathobiochemistry, hormonal signaling, disorders, hypothalamic-pituitary system, adrenal medulla steroid hormones, thyroid hormones, sex hormones Biochemistry of cancer, physical and chemical carcinogens, biological carcinogens, viral and cellular oncogenes, growth factors.
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Learning activities and teaching methods
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Monologic (reading, lecture, briefing), Dialogic (discussion, interview, brainstorming)
- Home preparation for classes
- 60 hours per semester
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Learning outcomes
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The aim of the course is to acquaint students with the problems of biochemical changes that accompany various diseases. It deals with the issue of important biomolecules (enzymes, proteins, nucleic acids) and biologically important low-molecular substances (sugars, amino acids, lipids, etc.), as well as disorders of biochemical processes occurring in the organism up to the molecular level. Students will learn the most modern techniques used in clinical biochemistry laboratories (liquid and gas chromatography, electrophoresis, mass spectrometry techniques, etc.). In the exercises, students practice important metabolic pathways, including their regulation. Furthermore, they learn about case reports, propose appropriate diagnostic procedures and learn to interpret the obtained results. Students are thus directed to consult obtained results with doctors.
After completing the course the student is able to orientate in the problems of pathological processes in the human organism.
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Prerequisites
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Not specified
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Assessment methods and criteria
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Oral examination
The exam is oral. The basic form of the exam is a discussion on selected topics. The degree of acquired knowledge is examined.
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Recommended literature
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Donald Voet, Judith G. Voet. Biochemie. Victoria Publishing, 1995. ISBN 80-85605-44-9.
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Jan Musil, Olga Nováková. Biochemie v obrazech a schématech. Praha: Avicenum, 1990. ISBN 08-109-89.
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Jaroslav Racek. Klinická biochemie. Praha: Galén, 2006. ISBN 80-7262-324-9.
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Marta Kalousková. Patobiochemie ve schématech. Praha: Grada, 2005. ISBN 80-247-1522-8.
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Miroslav Ledvina, Roman Kanďár. Přehled patobiochemie. Pardubice: Univerzita Pardubice, 2001. ISBN 80-7194-399-1.
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Peter Karlson, Wolfgang Gerok, Werner Gross. Pathobiochemie. Praha: Academia, 1987. ISBN 21-041-87.
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Roman Kanďár. Vybrané kapitoly z obecné biochemie, klinické biochemie a pathobiochemie. Pardubice: Univerzita Pardubice, 2015. ISBN 978-80-7395-964-7.
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Stanislav Štípek. Antioxidanty a volné radikály ve zdraví a nemoci. Praha: Grada, 2000. ISBN 80-7169-704-4.
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Tomáš Zima. Laboratorní diagnostika. Praha: Galén, 2007. ISBN 978-80-7262-372-3.
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