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Lecturer(s)
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Komersová Alena, doc. Ing. Ph.D.
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Pekárek Tomáš, Ing. Ph.D.
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Course content
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Basic conceptions, simple one-compartment pharmacokinetical models, renal drug elimination, metabolite pharmacokinetics, nonlinear pharmacokinetics, multicompartment pharmacokinetic models, pharmacokinetics following administration by intermittent intravenous infusion, pharmacokinetics - pharmacodynamics relationship.
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Learning activities and teaching methods
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Work with text (with textbook, with book)
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Learning outcomes
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The goal of the object is to obtain the basic knowledge about what the body is making with the drug after its administration (pharmacokinetics), what the drug is then making with the body (pharmacodynamics) and how to describe this behaviour on the basis of the laws of the formal reaction (chemical) kinetics, when the amount and the mode of the application of the drug are known
After graduation of the object the student will have the basic knowledge about the mutual behaviour of the living organism and the used drug with the possibility to describe and therefore to predict and control it to a certain extent.
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Prerequisites
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The knowledge of the reaction (chemical) kinetics.
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Assessment methods and criteria
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unspecified
Written and oral exam (questions and calculations)
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Recommended literature
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Hedaya M.A.:. Basic Pharmacokinetics. CRC Press, Taylor & Francis Group, Boca Raton, USA,, 2007.
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Kodíček M., Karpenko V. Biofyzikální chemie, Academia Praha 1977.
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Komers K., Čegan A., Komersová A., Machek J. Biofyzikální chemie. Pardubice: Univerzita Pardubice, 2003.
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