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Lecturer(s)
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Matvieiev Oleksandr, Ph.D.
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Pouzar Miloslav, prof. Ing. Ph.D.
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Course content
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1. Toxicology as a part of health risk assessment and management 2. Interaction of toxic substance with organism I - absorption a distribution 3. Interaction of toxic substance with organism II - biotransformation, excretion, recept. 4. Factors affecting effects of toxic substances 5. Limits for environmnental and occupational exposure to toxic substances 6. Nutrients a oxidative stress 7. Toxicology of heavy metals I - As, Hg 8. Toxicology of heavy metals II - Pb a Cd 9. Another toxic elements - Be, Al, Ni, Cr, Mn, Zn, Cu, Se, Ba, Tl, Ag 10. Toxicology of inorganic compounds of C 11. Toxicology of inorganic compounds of P, S a N 12. Toxicology of selected organic compounds 13. Carcinogens, mutagens and teratogens
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Learning activities and teaching methods
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Dialogic (discussion, interview, brainstorming), Work with text (with textbook, with book), Projection
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Learning outcomes
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The aim of lectures is to explain the basics of general and special toxicology with accent on problems occupational toxicology.
Students are well oriented in basics of general and experimental toxikology, they know toxic effects of elements and compounds selected as well as mechanisms of their toxicological activity and possibilities of toxicological risks reducing.
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Prerequisites
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Basic subject - there are not supposed any special skills or knowledge, only general competence of high school absolvent
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Assessment methods and criteria
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Didactic test
Exam test 100 %
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Recommended literature
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Hodgson, Ernest . A Textbook of modern toxicology. Hoboken: Wiley-Interscience, 2004. ISBN 0-471-26508-X.
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Klaassen C.D. Casarett & Doull's Toxicology: The Basic Science of Poisons (9th Edition). McGraw Hill / Medical, 2018. ISBN 978-1259863745.
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Kupec J. Toxikologie. Zlín: VUT, 1999.
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Linhart, Igor. Toxikologie : interakce škodlivých látek s živými organismy, jejich mechanismy, projevy a důsledky. Praha: Vysoká škola chemicko-technologická v Praze, 2012. ISBN 978-80-7080-806-1.
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Matrka M., Rusek V. Průmyslová toxikologie. Pardubice: VŠCHT, 1991.
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Paleček J., Linhart I., Horák J. Toxikologie a bezpečnost práce v chemii. Praha: VŠCHT, 1996.
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Pouzar M. Kalich hořkosti. Akademické nakladatelství CERM, 2013. ISBN 978-80-7204-851-9.
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Rusek V. Základy toxikologie a úvod do problematiky hygieny a bezpečnosti práce v chemické laboratoři. Pardubice: Univerzita Pardubice, 2001.
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