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Lecturer(s)
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Pouzar Miloslav, prof. Ing. Ph.D.
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Course content
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Absorption, distribution, metabolic conversion and excretion of toxic substance Biochemical mechanisms of toxic substance effects on human body Dose-response curves Toxicity testing Risk analysis and risk management in chemical industry Epidemiology and industrial toxicology Excursion to laboratory for toxicity testing Discussion of real problem from industrial toxicology area
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Learning activities and teaching methods
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Dialogic (discussion, interview, brainstorming), Work with text (with textbook, with book), Projection
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Learning outcomes
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Annotation: In the first part of the subject, general concepts of toxicology are briefly explained. Attention is paid namely to description of particular steps, which are involved in interaction of toxic substance with human body (concept ADME - absorption, distribution, metabolic conversion, excretion) and to explanation of main biochemical mechanisms of toxic effects. Subsequently, the construction and interpretation of dose-response curves is described. Introductory part is closed with problematic of laboratory metods for toxicity testing. Integral part of subject is excursion in toxicology laboratories of our industrial partner CETA-VUOS. Second part of the subject is devoted to problems of risk analysis and risk management and to interaction of industrial toxicology with these processes. Basics of epidemiologic approaches in industrial toxicology are explained. Last part of the subject is oriented on description and discussion of real problem from industrial toxicology area, which is connected with home country of the student.
Knowledge about general toxicology concepts, introduction to problematic of industrial toxicology and related fields, real contact with problems of laboratory testing of toxicity of chemicals
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Prerequisites
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Any special preliminary knowledge are not demanded
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Assessment methods and criteria
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Creative work analysis
Exam test 40 % Seminary work 30 % Presentation 30 %
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Recommended literature
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Hodgson E. A Textbook of Modern Toxicology, Fourth edition. John Wiley § Sons, Inc.Hoboken, New Jersey, 2010. ISBN 978-0-470-46206-5.
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Timbrell J. A. Introduction to Toxicology, Third edition. Taylor § Francis Ltd., 2002. ISBN 978-0415247634.
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