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Lecturer(s)
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Pouzar Miloslav, prof. Ing. Ph.D.
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Course content
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- toxicokinetics(absorption, distribution, biotransformation a excretion) - biochemical and cellular mechanisms of toxic effects - organ toxicity - dose-response curves - experimental toxicology, epidemiology, toxicological information - risk assessment and management in chemical industry - toxic metals - toxicology of selected inorganic substances - toxicology of selected organic substances - toxicology of nanomaterials
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Learning activities and teaching methods
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unspecified
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Learning outcomes
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The main aim of the subject is to explain how the toxic substances interact with organism on organ, cellular and biochemical level. The validity of above mentioned principles is then demonstrated on examples of specific substances.
After completing the course, the students understand the role of various parameters influencing the transport and transformation of toxic substances in the human body, they are able to estimate the biochemical mechanisms of toxic effect of selected groups of chemical substances, they are aware of the ways in which toxicological informations are acquired and processed, they understand the general term from risk assessment and risk management
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Prerequisites
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Knowledge of terms and general processes from cell and human biology on the high school level (for example book J. Bumerl a kol.: Biologie 1 a 2 pro střední odborné školy)
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Assessment methods and criteria
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Written examination
Successfull completion of written exam
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Recommended literature
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Hodgson Ernest. A Textbook of Modern Toxicology. John Wiley & Sons, 2011. ISBN 978-0-470-46206-5.
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Linhart, Igor. Toxikologie : interakce škodlivých látek s živými organismy, jejich mechanismy, projevy a důsledky. Praha: Vysoká škola chemicko-technologická v Praze, 2012. ISBN 978-80-7080-806-1.
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