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Lecturer(s)
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Pouzar Miloslav, prof. Ing. Ph.D.
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Course content
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Mechanistic toxicology - transport mechanisms through cell membrane and selective accumulation of xenobiotics, bioactivation of toxic substances, cell cycle, apoptosis and necrosis, signal transduction, specific inactivation of hormons, enzymes and neurotransmiters, molecular basic of chemical carcinogenese, xenobiotics with influence on cell metabolism
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Learning activities and teaching methods
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Dialogic (discussion, interview, brainstorming), Work with text (with textbook, with book), Projection
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Learning outcomes
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The aim of lectures is to explain cell and biochemical mechanisms of toxic effects of selected chemicals (microbial, plant and animal toxins, drugs and so on)
Students should be able to explain molecular or cell mechanism of toxic response for selected xenobiotics. They should be orinted in problems of toxicology of some bacterial, plant and animal toxins.
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Prerequisites
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Passing out the subjects Basics of Toxicology and Basics of Ecology or knowledge of corresponding topics
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Assessment methods and criteria
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Oral performance analysis
Seminary work and powerpoint presentation 100%
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Recommended literature
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Boelsterli U.A. Mechanistic Toxicology: The Molecular Basis of How Chemicals Disrupt Biological Targets. Taylor & Francis, 2002. ISBN 978-0415284592.
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Prokeš, Jaroslav. Základy toxikologie : obecná toxikologie a ekotoxikologie. Praha: Galén, 2005. ISBN 80-7262-301-X.
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Riedl O., Vondráček V. Klinická toxikologie. Avicenum, Praha, 1980. ISBN 08-075-80.
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Stone, Trevor. Léky, drogy, jedy. Praha: Academia, 2003. ISBN 80-200-1065-3.
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