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Lecturer(s)
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Bureš Filip, prof. Ing. Ph.D.
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Course content
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Introduction, history of organometallics. Polar organometallics (Na/K/Li/Mg/Zn). Grignard reagents. Organozinc compounds. Boron organometallics. Other organometallics of the main group metals. Organokovové sloučeniny přechodných kovů. Fundamental description of organometallics based on transition metals. Cross-coupling reactions (Heck, Suzuki-Miyaura, Stille, Negishi, Sonogashira, Hiyama, Buchwald-Hartwig etc.). DoM reactions. Allylic substitution. Carbene complexes. Particular industrial applications.
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Learning activities and teaching methods
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Monologic (reading, lecture, briefing)
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Learning outcomes
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Students of this course will get theoretically acquainted with the properties and preparation of organometallics based on the main group metals as well as on transition metals and their application in organic synthesis. This course further allows students to demonstrate and practice of the acquired knowledge on particular examples.
Students will mainly acquaint with a survey on the chemistry of organometalic compounds of (non)transition metals and with properties of the organometallics according to the particular metals and further with their preparation, characterization and finally also laboratory as well as industrial use.
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Prerequisites
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Main presupposition to manage the course are gained principles of basic organic chemistry and organic synthesis.
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Assessment methods and criteria
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Written examination
Written examination and its completion (max. 100 points) gain the final grade. Unsuccessful students will pass oral examination.
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Recommended literature
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A. de Meijere, F. Diederich:. , Metal-Catalyzed Cross-Coupling Reactions 2004, WILEY-VCH, Weinheim. Second Edition, Vol. 1 a 2..
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C. Elschenbroich:. Organometallics 2006, WILEY-VCH, Weinheim. Third, Completely Revised and Extended Edition..
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D. Dvořák:. Chemie organokovových sloučenin přechodných kovů 1994, skriptum, VŠCHT Praha..
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E. V. Anslyn, D. A. Dougherty:. Modern Physical Organic Chemistry, 2006, University Science Books, New York. Chapter 12: Organotransition Metal Reaction Mechanism and Catalysis..
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M. Schlosser:. , Organometallics in Synthesis 1994, John Wiley & Sons Ltd., Chichester..
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P. Knochel:. Handbook of Functionalized Organometallics 2005, WILEY-VCH, Weinheim. Vol. 1 a 2..
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