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Lecturer(s)
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Hrdina Radim, prof. Ing. CSc.
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Pejchal Vladimír, doc. Ing. Ph.D.
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Course content
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Week 1 - Current trends in organic production technology. Week 2 - Basic technological operations of organic substance production Week 3 - Basic types of production equipment used in organic production technology. Week 4 - Technology to make amines and use them in the production of organic specialties. Week 5 - Technology for the production of alcohols and phenols and their use in the production of organic specialties. Week 6 - Phosgene production technology and its use in the production of organic specialties. Week 7 - Technology of the production of chlorides and anhydrides of acids and its use in the production of organic specialties. Week 8 - Technology to produce chloroformmiates, carbonates and carbamates and use them in the production of organic specialties. Week 9 - Technology of production of isocyanates, carbamyl chlorides and urea, and their use in the production of organic specialties. Week 10 - Technology of esters and amides production and their use in the production of organic specialties. Week 11 - Technology for the production of nitriles and heterocyclicals Week 12 - Drug manufacturing technology in good manufacturing practice mode - SVP (GMP), clean rooms. Week 13 - Applied Research, Up scaling, translating laboratory results into practice. Documentation of the results of laboratory development and production documentation.
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Learning activities and teaching methods
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unspecified
- Contact teaching
- 39 hours per semester
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Learning outcomes
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The aim of the course is to introduce the audience to the development of organic speciality technology with a focus on pharmaceuticals and medicinal products, including starting materials and intermediates.
The aim of the course is to introduce the audience to the development of organic speciality technology with a focus on pharmaceuticals and medicinal products, including starting materials and intermediates.
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Prerequisites
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The student must have the basics of undergraduate physics, inorganic and organic chemistry, the basics of physical chemistry, all at the level of a successfully completed bachelor's degree.
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Assessment methods and criteria
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Oral examination
The student must have the basics of undergraduate physics, inorganic and organic chemistry, the basics of physical chemistry, all at the level of a successfully completed bachelor's degree.
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Recommended literature
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Hampl F., Rádl S., Paleček J. Farmakochemie. Praha, 2007.
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Johnson, D. The Art of Drug Synthesis. 2007.
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Kuchař M. Výzkum a vývoj léčiv. Praha, 2007.
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