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Lecturer(s)
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Drabina Pavel, doc. Ing. Ph.D.
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Imramovský Aleš, prof. Ing. Ph.D.
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Sedlák Miloš, prof. Ing. DrSc.
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Course content
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Object of pharmaceutical chemistry, basic notions - pharmacology, pharmacognosy, galenic pharmacy, medicinal drug, form of medicinal drug. Basic principles of general pharmacology - way of administration, fate of drug in organism: absorption, transport and distribution, metabolism (bio-transformations - oxidation, reduction, hydrolysis, conjugation, non-enzymatic transformations), excretion. Effects of medicinal drugs - specific and non-specific effect - relationships between structure and effect. Problems of research and development of new pharmaceuticals. European and Czech Pharmacopoeias, classification of drugs from pharmacological standpoint. General anaesthetics - mechanism of action. Syntheses of fluorine-containing inhalation anaesthetics (halothane), general intravenous anaesthetics (thiopental). Hypnotics and sedatives - effect and application. Syntheses of selected hypnotics of the 1st to 3rd generations.:
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Learning activities and teaching methods
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Monologic (reading, lecture, briefing), Dialogic (discussion, interview, brainstorming)
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Learning outcomes
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Strategy for Organic Drug Synthesis and Design.
Absolvents are Able Applicate Strategy for Organic Drug Synthesis and Design.
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Prerequisites
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KOCH/C008 - Organic chemistry I KFCH/C014 - Principles of Physical Chemistry
UOCHT/C008 and UOCHT/C511
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Assessment methods and criteria
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Oral examination, Written examination
Understanding and active knowledge of Basic organic synthesis.
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Recommended literature
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Holý A.:. PRINCIPY BIORGANICKÉ CHEMIE VE VÝVOJI ANTIVIROTIK A CYTOSTATIK, Univerzita Palackého V Olomouci, Olomouc 2004, [ISBN 80-244-0855-4]..
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Paleček J., Hampl F.:. FARMAKOCHEMIE, skripta 2.vydání, VŠCHT Praha 2002,[ISBN 80-7080-495-5]..
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