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Lecturer(s)
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Tydlitát Jiří, Ing. Ph.D.
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Klikar Milan, Ing. Ph.D.
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Drabina Pavel, doc. Ing. Ph.D.
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Hanusek Jiří, prof. Ing. Ph.D.
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Šimůnek Petr, doc. Ing. Ph.D.
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Kulhánek Jiří, prof. Ing. Ph.D.
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Pařík Patrik, Ing. Ph.D.
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Course content
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pH Measurement in different media, standards, standardization, buffers, pH a pK assignment, kinetic measurement (presentation of methods and instruments). UV-VIS Spectra measurement, spectral pK determination of weak acid, stopped-flow method of measuring of rapid reactions. (presentation of methods and instruments). Spectral observation of base catalyzed reaction in pseudo-first order conditions, influence of base catalyst concentration, influence of temperature, activation parameters estimation. UV/VIS Spectral observation of charge transfer complex, dependence of maximum of absorbance on donor bazicity, substituent effects. Spectral determination of dissociation constant of model substrate. Potentiometric determination of dissociation constants of the serie of model compounds in non-aqueous media. Study of rapid reaction of model compound using stopped-flow technique. Analysis of unrecognized reaction mixture using GC/MS technique. 1H and 13C NMR spectroscopy, sample preparation, measuring of model compound spectrum, interpretation of spectrum of unrecognized chemical. Elemenal analysis, sample preparation, presentation of technique and measurement.
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Learning activities and teaching methods
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Methods of individual activities, Laboratory work
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Learning outcomes
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The main aim of the course unit is to introduce and practise main patterns of physical organic chemistry. Education proceeds in using of experimental techniques as spectral, kinetic, pH, and pK measurement, which are usually used for observation and study of physical and chemical properties of organic compounds. Students use instrumentation of institute, individually solve specific problems from the area of physical organic chemistry using model compounds.
After graduation, student can individually apply experimental techniques usually used for study of physical and chemical properties of organic compounds. He is able to offer experimental technique for solving particular problem, to set experiment, to realize measurement, and after this, he can analyze and interpret results of experiment.
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Prerequisites
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Fundamental knowledge of organic, physical, and analytical chemistry chemistry in the range of bachelor study
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Assessment methods and criteria
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Student performance assessment
Understanding and active training of fundamental physical methods using in the study of properties of organic compounds
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Recommended literature
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Exner O.:. Korelační vztahy v organické chemii, SNTL Praha 1981..
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Exner O.:. Struktura a fyzikální vlastnosti organických sloučenin. SNTL, Praha, 1985..
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Štěrba V., Panchartek J.:. Kinetické metody při studiu reakcí organických sloučenin. SNTL, Praha, 1985..
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Vetešník P., Pytela O.:. Laboratorní cvičení z fyzikální organické chemie. Skriptum VŠCHT Pardubice, Pardubice, 1985..
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