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Lecturer(s)
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Kulhánek Jiří, prof. Ing. Ph.D.
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Course content
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Terminology of heterocyclic compounds, retrosysthetic procedures, synthesis of heterocycles with the circle from 3 to 6 members of chain and condensed systems with oxygen as the heteroatom, synthesis of heterocycles with the circle from 3 to 6 members of chain and with one or more nitrogen as the heteroatom, synthesis of systems with more that 6-membered circle and condensed heterocycles with nitrogen as heteroatom, synthesis of heterocycles contained sulphur, synthesis of heterocycles with more type of heteroatom As, P, Sb, Se, Si, physical characteristics of heterocyclic compounds, electrophilic and nucleophilic substitutions, reactions of heterocycles with organometallic compounds, oxidizing, reducting and photogenic reactions on heterocyclic systems, using of heterocycles as protecting and activating group, natural compounds contain heterocycles.
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Learning activities and teaching methods
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Monologic (reading, lecture, briefing)
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Learning outcomes
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The aim of the course is acquainted students with synthesis of heterocyclic compounds and their reactions. It is based on using retrosynthetic methods and ability to take bearings in various methods of preparations. Students have to recognize places of reactivities of particular compounds and estimate their physical and chemical characteristics. They have to be able to use knowledge in the field of organic compounds and apply them on the heterocyclic compounds.
Having finished this course students are able to design synthesis of any heterocyclic compounds and choose the best method. Students orientate themselves in the field of reactivity of heterocycles and are able to use it to prepare new compounds.
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Prerequisites
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The fundamental knowledge of organic synthesis and reactivity of organic compounds
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Assessment methods and criteria
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Oral examination
The ability of exploited a combined of knowledge of organic chemistry in synthesis a reaction of heterocyclic compounds.
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Recommended literature
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Eicher T., Hauptmann S.:. The Chemistry of Heterocycles. Verlag, New York 1995. ISBN 3 13 100511 4..
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Katritzky A. R., Pozharskii A. F.:. Handbook of Heterocyclic Chemistry, 2nd Edition. Pergamon, Amsterdam 2000..
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Parashar N.K., Negi M. Chemistry of Heterocyclic Compounds. New Delhi, 2015.
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