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Lecturer(s)
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Kulhánek Jiří, prof. Ing. Ph.D.
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Course content
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Cyclocondensation and cycloaddition principles in the synthesis of heterocyclic systems. Synthesis of three to seven membered rings containing oxygen, nitrogen and sulfur and their combinations. Synthesis of heterocyclic precursors useful in cross-coupling reactions. Synthesis of sulfur and nitrogen derivatives with practical applications in materials chemistry. Modification of functional groups present on the heterocyclic ring. Synthetic procedures leading to ring enlargement or reduction, heteroatom exchange.
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Learning activities and teaching methods
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Work with text (with textbook, with book)
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Learning outcomes
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The aim of the course is to deepen knowledge in the field of synthesis of heterocyclic compounds using retrosynthetic procedures. Based on structures, estimate the physicochemical properties and reactivity of the studied derivatives.
After completing the course, students are able to design the synthesis of any heterocyclic compounds and choose the optimal method. They are familiar with the reactivity of heterocycles and can use it in the preparation of new substances.
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Prerequisites
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Advanced knowledge of organic synthesis and basics of heterocyclic chemistry.
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Assessment methods and criteria
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Oral examination
Apply knowledge of organic chemistry and combine this knowledge with the basics of heterocyclic synthesis.
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Recommended literature
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Eicher T., Hauptmann S.:. Handbook of Heterocyclic Chemistry, 2nd Edition. Pergamon. New York, 2008.
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Grimmet, M. Ross. Imidazole and benzimidazole synthesis. London, 1997.
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Katritzky A. R., Pozharskii A. F.:. Handbook of Heterocyclic Chemistry, 2nd Edition. Pergamon. Amsterdam, 2000.
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Parashar N.K., Negi M. Chemistry of Heterocyclic Compounds. New Delhi, 2015.
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Perepichka I.F., Perepichka D.F. Handbook of thiophene-based materials. Chichester, 2009.
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