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Lecturer(s)
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Sedlák Miloš, prof. Ing. DrSc.
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Course content
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The subject describes the retrosynthetic approach for the design of the synthesis of specific organic compounds. The strategy and tactics in the general schedule of synthesis for multistep synthesis. The different types of synthons that represents the formal synthetic units and their corresponding practical reagents. The current synthetic methods using both traditional and organometallic compounds in the formation of C-C bonds and the transformations and the protection of the functional groups. The synthesis of proposals are documented and discussed using examples in different classes of organic compounds, which are divided to non-functional, monofunctional, polyfunctional compounds, carbocycles and peptides. In the synthesis are dealt with questions of chemo-and regioselectivity, and the application of catalysts to achieve defined stereoselectivity.
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Learning activities and teaching methods
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unspecified
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Learning outcomes
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The aim of the study is to teach students to independently design synthesis of complex organic compounds.
Ability to develop proposals for synthesis of complex organic compounds on the basis of retro-synthetic analysis.
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Prerequisites
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The prerequisite for study is to complete a Master's degree in the study programme Chemistry and Chemistry of Materials, Chemistry, Chemical and Process Engineering and Special Chemical and Biological Disciplines at the Faculty of Chemical Technology of the University of Pardubice. It is also open to graduates of similar study programmes at other universities in the Czech Republic and the EU.
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Assessment methods and criteria
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unspecified
Knowledge of organic chemistry in the scope of master's degree.
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Recommended literature
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Carey F.A., Sundberg R.J.. Advanced Organic Chemistry, Part B: Reaction and Synthesis. New York, 2007. ISBN 978-0-387-68350-8.
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Fuhrop J.H., Li G. Organic Synthesis: Concepts and Methods. Wienheim, 2003. ISBN 3-527-30273-5.
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Tietze L.F., Eicher T., Diderichsen U., Spiecher A. Reaction and Synthesis In the Organic Chemistry Laboratory. Wienheim, 2015. ISBN 978-3-527-33814-.
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