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Lecturer(s)
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Plášilová Eva
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Vošmik Milan, doc. MUDr. Ph.D.
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Buka David, MUDr.
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Petera Jiří, prof. MUDr. Ph.D.
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Sirák Igor, doc. MUDr. Ph.D.
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Course content
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Cell cycle control. Carcinogenesis. Biology of cancer. TNM staging system, histological classification of tumours. Epidemiology of cancer, National oncological register. Multidisciplinary cancer treatment. Chemotherapy and biological treatment principles. Organization of cancer treatment in the Czech Republic. Key cell structures and radiation impact. Radiation damage recovery. Radiosensitivity and radioresistance of tumours and healthy tissues, influencing factors. Effect of oxygen. Repopulation, redistribution, reoxygenation. Stochastic and non-stochastic effects of radiation. Tolerance of tissues and organs regarding radiation. Treatment of side effects of radiation therapy. Utilization of a high linear transfer radiation. Radiobiological models. Clinical applications of radiobiological principles, fractionation, conformal radiotherapy, brachytherapy, radiosensitizers and radioprotectors, chemoradiotherapy. Radiobiology of brachytherapy with low and high dose rate. Hyperthermia and its utilization. Anticancer radiation therapy in clinical practice, radical, palliative, preoperative, postoperative. Principles of radiotherapy in non-cancerous diseases. Characteristics of photon, electron, and corpuscular beams of radiation. Radiation exposure and dose in radiotherapy and their measurement. Principles and layout of workplace for brachytherapy. Radiation protection, legislation regarding workplace with ionizing radiation sources. Simulator utilization. Work with planning system. CT simulator. Operating linear accelerator. Physical measurement on a linear accelerator.
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Learning activities and teaching methods
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Monologic (reading, lecture, briefing), Demonstration, Skills training
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Learning outcomes
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The aim of the subject is to acquaint students with radiation oncology. Students will gradually acquire the basic knowledge and skills concerning oncological care facilities, the possibilities for combinations of individual therapeutic procedures, and the principles of radiation effects. Individual radiation techniques are explained, and so are radiotherapy plans for oncological as well as nononcological diagnoses.
Students will acquire knowledge and skills within the scope of the subject syllabus and will be ready to use them in radiotherapy clinical practice
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Prerequisites
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unspecified
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Assessment methods and criteria
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Written examination, Home assignment evaluation
Completion of compulsory 80% attendance at the practicum sessions and seminars.
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Recommended literature
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NOVOTNÝ, J.; VÍTEK, P.; PETRUŽELKA, L. Klinická a radiační onkologie pro praxi. 1. vyd. Praha : Triton, 308 s., 2005.
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PETERA, J. et al. Intraluminární brachyterapie. Praha: Galén, 2001.
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PETERA, J. et al. Obecná onkologie. Praha: Karolinum, 2005. ISBN 80-246-0968-1.
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SOUMAROVÁ, R.; HOMOLA, L. Intersticiální brachytherapie. 1. vyd. MU Brno, Standardy radiační onkologie/radioterapie: www.srobf.cz, 2006. ISBN 20070913.
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ŠLAMPA, P. et al. Radiační onkologie v praxi. Brno: Masarykův onkologický ústav, 2007.
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ŠLAMPA, P.; PETERA, J. et al. Radiační onkologie. Praha: Galén, Karolinum, 2007.
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