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Lecturer(s)
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Plášilová Eva
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Petera Jiří, prof. MUDr. Ph.D.
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Course content
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Cell cycle control. Carcinogenesis. Biology of cancer. TNM staging system, histological classification of tumours. Epidemiology of cancer, National oncological register. Multidisciplinary cancer treatment. Chemotherapy and biological treatment principles. Organization of cancer treatment in the Czech Republic. Key cell structures and radiation impact. Radiation damage recovery. Radiosensitivity and radioresistance of tumours and healthy tissues, influencing factors. Effect of oxygen. Repopulation, redistribution, reoxygenation. Stochastic and non-stochastic effects of radiation. Tolerance of tissues and organs regarding radiation. Treatment of side effects of radiation therapy. Utilization of a high linear transfer radiation. Radiobiological models. Clinical applications of radiobiological principles, fractionation, conformal radiotherapy, brachytherapy, radiosensitizers and radioprotectors, chemoradiotherapy. Radiobiology of brachytherapy with low and high dose rate. Hyperthermia and its utilization. Anticancer radiation therapy in clinical practice, radical, palliative, preoperative, postoperative. Principles of radiotherapy in non-cancerous diseases. Characteristics of photon, electron, and corpuscular beams of radiation. Radiation exposure and dose in radiotherapy and their measurement. Principles and layout of workplace for brachytherapy. Radiation protection, legislation regarding workplace with ionizing radiation sources. Simulator utilization. Work with planning system. CT simulator. Operating linear accelerator. Physical measurement on a linear accelerator.
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Learning activities and teaching methods
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Monologic (reading, lecture, briefing), Demonstration, Skills training
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Learning outcomes
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The aim of the course is to acquaint students with the issue of radiation oncology. Teaching takes place in three semesters and students gradually acquire basic knowledge and skills from the organization of oncological care, with the possibility of combining individual treatments and principles of radiation at the molecular, cellular, tissue and also at the level of the whole organism. Individual irradiation techniques are explained, including the planning of radiation treatment for oncological ones, but even with non-tumorous diagnoses.
Students will acquire knowledge and skills within the scope of the subject syllabus and will be ready to use them in radiotherapy clinical practice
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Prerequisites
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unspecified
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Assessment methods and criteria
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Written examination, Home assignment evaluation
mandatory 80% participation in practical exercises passing the oral exam
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Recommended literature
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Binarová, Andrea. Radioterapie. Ostrava: Ostravská univerzita v Ostravě Fakulta zdravotnických studií, 2010. ISBN 978-80-7368-701-4.
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Hynková, Ludmila. Základy radiační onkologie. Brno: Masarykova univerzita, 2012. ISBN 978-80-210-6061-6.
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NOVOTNÝ, J.; VÍTEK, P.; PETRUŽELKA, L. Klinická a radiační onkologie pro praxi. 1. vyd. Praha: Triton, 308 s., 2005.
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PETERA, J. a kol. Intraluminární brachyterapie. 1. vyd. Praha: Galén, 103 s., 2001. ISBN 80 7262-116-6.
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PETERA, J. a kol. Obecná onkologie. 1. vyd. Praha: Karolinum, 205 s., 2005. ISBN 978 802 4609 683.
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Seidl, Zdeněk. Radiologie pro studium i praxi. Praha: Grada, 2012. ISBN 978-80-247-4108-6.
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SOUMAROVÁ, R.; HOMOLA, L. Intersticiální brachyterapie. www.srobf.cz, 2006. ISBN 80-210-4107-2.
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ŠLAMPA, P.; PETERA, J. a kol. Radiační onkologie. 1. vyd. Praha: Galén, Karolinum, 457 s., 2007. ISBN 978-80-7262-469-0.
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ŠLAMPA, P. et al. Radiační onkologie v praxi. 3. vyd. Brno: Masarykův onkologický ústav, 2011. ISBN 978-80-86793-19-1.
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