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Lecturer(s)
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Korecká Lucie, doc. RNDr. Ph.D.
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Course content
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Inorganic and polymeric nanomaterials for medical applications - nanoparticles, nanofibers, nanogels. Properties and structure of individual types of materials, comparison from the point of view of usability - biocompatibility vs. toxicity . Modification of nanomaterials with low molecular weight and high molecular weight molecules - choosing the appropriate material regarding to the size of the molecule used for modification. Physical and chemical methods of modification of biomedical materials - basic division of methods, principles, effectiveness in the context of the resulting application . Overview of functional groups of biomolecules (low molecular weight and high molecular weight) useful for immobilization - oriented and non-oriented binding, reactivity of groups, stability of the resulting binding. Activating, conjugating agents and stabilizing agents - activation of materials vs. activation of ligands used for modification, influence of chemical nature of activating agents on biocompatibility of modified materials . Verification methods for verifying the effectiveness of material modification - basic and advanced methods for verifying the effectiveness of modification.
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Learning activities and teaching methods
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Monologic (reading, lecture, briefing), Dialogic (discussion, interview, brainstorming), Work with text (with textbook, with book)
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Learning outcomes
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The aim of the course is to provide an overview of materials that are used for biomedical applications, both therapeutically (drug delivery systems, covering materials, etc.) and diagnostically (detection markers for imaging and diagnostic methods). The subject is based on bioinorganic and bioorganic chemistry, biochemistry. Students will get information about individual types of materials from the point of view of their structure, chemical nature and physical properties. These properties will be discussed in the context of their appropriate use in biomedicine (in vivo, in vitro, biocompatibility, etc.). The second key goal of the course is to provide information on methods of surface modification of biomedical materials with low- and high-molecular substances (proteins, carbohydrates, therapeutics, diagnostic markers, etc.). Specific methods of modification and bioconjugation will be described, and at the same time methods of verification of the effectiveness of the modification will be mentioned.
The student will obtain information regarding biomedical materials and their modification techniques. Based on his knowledge, he will be able to choose a suitable method, a suitable material for the required application and predict the usability of the given material. Based on the requirements of the final application, he will be able to choose effective material preparation procedures.
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Prerequisites
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unspecified
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Assessment methods and criteria
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Oral examination
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Recommended literature
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ANNU (ed.). Biopolymers for Biomedical Applications. Hoboken: Scrivener Publishing, 2024. ISBN 978-1119-86545-2.
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BLANCO, A., BLANCO, G. Medical biochemistry. 2nd ed. London: Academic Press, 2022. ISBN 978-0-323-91599-1.
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HERMANSON, GREG T. Bioconjugate techniques. 2012.
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INGAN, L. ED. Biomaterials and materials for medicine. Taylor & Francis Ltd., 2021. ISBN 978-0367753219.
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SOUGATA, J., SUBRATA, J. Functional biomaterials: drug delivery and biomedical applications. Springer Verlag, 2022. ISBN 978-981-16-7152-4.
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