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Lecturer(s)
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Pejchalová Marcela, doc. Ing. Ph.D.
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Course content
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Metabolism of different groups of microorganisms . Sporogenesis, cell cycle, secretion of low and high molecular substances . Action of antimicrobial agents . Mechanisms influencing the pathogenicity of microorganisms . Quorum sensing and biofilm formation . Responses of microorganisms to different types of stress, VBNC state of cells.
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Learning activities and teaching methods
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Monologic (reading, lecture, briefing), Dialogic (discussion, interview, brainstorming), Work with text (with textbook, with book)
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Learning outcomes
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The aim of the course is to introduce the students to the biochemistry of microorganisms with a focus on the organization of cellular metabolism and regulatory mechanisms. Furthermore, students will learn about the determinants of pathogen virulence, the synthesis of antimicrobial peptides and antibiotics. The principles of microbial regulation by the quorum-sensing system are explained.
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Prerequisites
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unspecified
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Assessment methods and criteria
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Written examination, Home assignment evaluation
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Recommended literature
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COHEN, G. N. Microbial biochemistry.. Dordrecht: Kluwer Academic Publishing, 2004. ISBN 1-4020-1541-0.
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FINLAY, J. M. Mikrobiom lidského těla.. Praha: Stanislav Juhaňák - Triton, 2020. ISBN 978-80-7553-777-5.
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FISCHETTI, V. A., NOVICK, R. P., FERRETTI, J. J.; PORTNOY, D. A., BRAUNSTEIN, M. et al. Gram-positive pathogens.. Third edition. Washington, DC: ASM Press, 2019. ISBN 978-1-68367-012-4.
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MALOY, S. R., CRONAN, J. E., FREIFELDER, D. Microbial genetics.. 2nd ed. Boston: Jones and Bartlett, 1994. ISBN 0-86720-248-3.
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PERSING, DAVID H. (ed.). Molecular microbiology: diagnostic principles and practice.. 2nd ed. Washington ASM Press, 2011. ISBN 978-1-55581-497-7.
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