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for academic year 2025/2026
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Course: Advanced materials and their applications in biomedicine

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Course title Advanced materials and their applications in biomedicine
Course code FZS/D2MBI
Organizational form of instruction Lecture
Level of course Doctoral
Year of study not specified
Semester Winter and summer
Number of ECTS credits 0
Language of instruction Czech
Status of course Compulsory-optional
Form of instruction Face-to-face
Work placements This is not an internship
Recommended optional programme components None
Lecturer(s)
  • Bílková Zuzana, prof. RNDr. Ph.D.
Course content
Technology and overview of materials suitable for biomedical applications. Physico-chemical properties of materials and their classification. Criteria for the selection of suitable materials. Nanomaterials of the new generation - production, properties, toxicity, pharmacokinetic properties. Metal, ceramic, polymer and composite materials for tissue engineering. 3D materials based on hydrogels for reconstructive and plastic surgery. Synthetic and polymeric biocompatible materials - wound coverings and wound healing support. Nanoparticles from natural biopolymers (micelles, liposomes, polysaccharides). Nanoparticles for targeted drug transport. Production of vaccines based on biopolymer nanoparticles. (Nano)materials (e.g. based on metals, quantum dots, magnetic particles) for in vitro diagnostics . (Nano)materials suitable for in vivo diagnostics (imaging methods) and therapy.

Learning activities and teaching methods
Monologic (reading, lecture, briefing), Dialogic (discussion, interview, brainstorming), Work with text (with textbook, with book)
  • Contact teaching - 8 hours per semester
  • Term paper - 7 hours per semester
  • Preparation for an exam - 32 hours per semester
Learning outcomes
New technologies and new materials developed in last decades find the applications in various areas of human activity, medical sciences are no exception. Already today, clinical practice clearly shows the benefit and potential of (nano)materials in modern and so-called personalized medicine. And we are just at the beginning. Many current results of science and research are now being verified in clinical trials. Promising results indicate that modern medicine counts with the (nano)materials not only in the diagnostics but mainly in therapy. The diagnostics and therapy in accordance with the principles of "Evidence-based practice in Health Sciences" thus enters a new era of medicine and biomedical sciences. As part of the subject, we want to familiarize students with the development, production and classification of materials used in biomedicine, with nanobiomaterials of the new generation, with their preparation, method of use or evaluation of toxicity (biocompatibility) and the process of their in vivo degradation. We will also focus on interesting applications, e.g. metal, ceramic, polymer and composite biomaterials for tissue engineering, for targeted drug transport, for in vivo and in vitro diagnostics and therapy.

Prerequisites
unspecified

Assessment methods and criteria
Oral examination, Written examination, Home assignment evaluation

Recommended literature
  • ABATANGELO, G., VINDIGNI, V., AVRUSCIO, G., PANDIS, L., BRUN, P. Hyaluronic acid: redefining its role. Cells, roč. 9, č. 7. 2020.
  • AGRAWAL, R. et al. Biomaterial types, properties, medical applications, and other factors: a recent review. Journal of Zhejiang University-SCIENCE A., roč. 24, č. 11, s. 1027-1042. 2023.
  • ANGELOPOULOU A. Nanostructured biomaterials in 3D tumor tissue engineering scaffolds: regenerative medicine and immunotherapies. International Journal of Molecular Sciences, roč. 25, č. 10. 2024.
  • BARDHAN, N. Nanomaterials in diagnostics, imaging and delivery: Applications from COVID-19 to cancer. MRS Communications, roč. 12, č. 6, s. 1119-1139. 2022.
  • ERTAS, Y.N., MAHMOODI, M., SHAHABIPOUR, F. et al. Role of biomaterials in the diagnosis, prevention, treatment, and study of corona virus disease 2019 (COVID-19). Emergent Materials. 2021, roč. 4, č. 1, s. 35-55.
  • GUPTA, S., KAUR, R., BHARDWAJ, A. et al. Multifunctional nanomaterials: recent advancements in cancer therapeutics and vaccines. Indian Journal of Microbiology.
  • HONG, J., WANG, L., ZHENG, Q., CAI, C., YANG, X., LIAO, Z. The Recent applications of magnetic nanoparticles in biomedical fields. Materials. 2024, roč. 17, č. 12.
  • HUANG, T. et al. Application and development of electrospun nanofiber scaffolds for bone tissue engineering. ACS Biomaterials Science & Engineering, roč. 10, č. 7, s. 4114-4144. 2024.
  • HYDER, A., ALI, A., BULEDI, J. A., MEMON, A.A., IQBAL, M., BANGALNI, T.H., SOLANGI, A.R., THEBO, K.H., AKHTAR, J. Nanodiamonds: a cutting-edge approach to enhancing biomedical therapies and diagnostics in biosensing. The Chemical Record, roč. 24, č. 4. 2024.
  • KUMAR, C. S. S. R. (ed.). Nanotechnologies for the Life Sciences. Online.. Wiley, 2007. ISBN 978-3-5273-1301-3.
  • KUMBHAR, P.R., KUMAR, P., LASURE, A. et al. An updated landscape on nanotechnology-based drug delivery, immunotherapy, vaccinations, imaging, and biomarker detections for cancers: recent trends and future directions with clinical success. Discover Nano, roč. 18, č. 1. 2023.
  • LIAO, Z., HUANG, J., LO, PC., LOVELL, JF., JIN, H., YANG, K. Self-adjuvanting cancer nanovaccines. Journal of Nanobiotechnology. 2022, roč. 20, č. 1.
  • LUO, GF., ZHANG, XZ. Magnetic nanoparticles for use in bioimaging. Biomaterials Science, roč. 12, č. 24, s. 6224-6236. 2024.
  • MENAGADEVI, M. et al. Biomaterials and Their Applications. Biomedical Materials & Devices. 2024.
  • SUN, L., et al. Antibacterial nonwoven materials in medicine and healthcare. Journal of Biomaterials Applications.
  • WEI, H., HU, Y., WANG, J., GAO, X., QIAN, X., TANG, M. Superparamagnetic iron oxide nanoparticles: cytotoxicity, metabolism, and cellular behavior in biomedicine applicationsInternational Journal of Nanomedicine. 2021, roč. 16, s. 6097-6113.
  • ZHU, P. et al. Carbon Dots in Biomedicine: A Review. ACS Applied Bio Materials, roč. 5, č. 5, s. 2031-2045. 2022.


Study plans that include the course
Faculty Study plan (Version) Category of Branch/Specialization Recommended year of study Recommended semester
University of Pardubice, date of update: 16.03.2026 23:51. Data created for academic year 2025/2026