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Lecturer(s)
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Bílková Zuzana, prof. RNDr. Ph.D.
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Course content
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Personalized medicine (precision medicine, tailor-made medicine) - introduction, definition and terminology, assignment of a seminar paper . Personalized health care - lifestyle, nutrition, prevention, functional medicine, diagnostics, therapy, palliative medicine, meaning of placebo. Teamwork of doctors and paramedics. Personalized medicine in oncology - genomic profiling, pharmacogenetics, immunotherapy, biological treatment, patient information about the course of the disease, treatment, patient trust in the doctor. Methods of monitoring individuals in health and illness; new trends in diagnostics (self-tests, POCT, multiplex analyses), differential diagnostics, examination algorithms, diagnostic and therapeutic biomarkers, sensitivity and specificity of assays, ROC curve. Reproductive medicine. Biomedical research. Phenogenomics. Clinical registries and trials. Open-access database. "Big" data. Tools of biostatistics and bioinformatics. Artificial Intelligence. Legal and ethical issues of personalized medicine, effective protection/sharing of sensitive personal data. Performance and cost-effectiveness of a personalized approach in healthcare.
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Learning activities and teaching methods
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Monologic (reading, lecture, briefing), Dialogic (discussion, interview, brainstorming), Work with text (with textbook, with book)
- Contact teaching
- 12 hours per semester
- Home preparation for classes
- 6 hours per semester
- Writing a seminar paper
- 6 hours per semester
- Preparation for an exam
- 20 hours per semester
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Learning outcomes
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Personalized medicine (Personalized Medicine or Precision Medicine) is a field that focuses on investigating the health and personal needs of individuals. The field consists of prevention, diagnosis, treatment and subsequent personalized care. To this end, it uses methods that provide accurate and complete data about individuals throughout patient care. The methods include a wide range of examinations that provide a complete picture of the health/disease of a particular individual. The content of the theme is to introduce the most modern procedures and methods that enable such a comprehensive and tailored approach to the individual. Data processing is an essential component of this field. However, personal medicine raises many legal and ethical issues, so it is also discussed.
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Prerequisites
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unspecified
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Assessment methods and criteria
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Oral examination, Home assignment evaluation
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Recommended literature
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BALCH, B. Making medicine personal: moving away from a one-size-fits-all approach to health care. AAMC, 2024.
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BASHARAT S., SMITH, A., DARVESH N. et al. 2023 Watch List: Top 10 precision medicine technologies and issues. Canadian Agency for Drugs and Technologies in Health, 2023.
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BIERMAN, A. S., BURKE, B. T., COMFORT, L. N., GERSTEIN, M., MUELLER, N. M. et al. From precision medicine to precision care: choosing and using precision medicine in the context of multimorbidity. Cambridge Prisms: Precision Medicine, 2023.
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British Heart Foundation. Heart Matters. British Heart Foundation. 2022.
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EUROPEAN COMMISSION. Personalised medicine. Research and innovation.
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GOETZ, L. H., SCHORK, N. J. Personalized medicine: motivation, challenges, and progress. Fertility and Sterility, roč. 109, č. 6, s. 952-963. 2018.
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JAIN, K. K. Textbook of personalized medicine. Cham: Springer International Publishing, 2021. ISBN 978-3-030-62079-0.
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KEOGH, B. Personalised medicine strategy. NHS England, 2015.
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PMC. The Age of personalised medicine.
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SHERER, A. Precision medicine. 3rd ed. [Bozeman]: Golden Helix, 2021. ISBN 978-0-9908886-5-9.
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STEFANICKA-WOJTAS, D., KURPAS, D. Personalised medicine-implementation to the healthcare system in Europe (Focus Group Discussions). Journal of Personalized Medicine, roč. 13, č. 3. 2023.
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