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Lecturer(s)
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Šiller Michal, Mgr. Ph.D.
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Šmíd Lenka, Mgr. Ph.D.
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Mladěnka Přemysl, PharmDr. Ph.D.
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Course content
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Introduction - distribution of pharmacology, basic terms (curative substance - curative preparation - medicine). Medicine and curative preparation names, where to find information about medicines. Distribution of general pharmacology, classification of system pharmacology. Development of new medicines I. Modifications of chemical structure targeted to potential pharmacotherapeutic benefit. Examples of benefit of non-pharmacological braches (pathobiochemistry, clinical and pathological physiology). Pharmacological preclinic tests. Development of new medicines II. Toxicological tests. Alternative toxicological tests replacing animal models. Pharmacokinetics I. Cell membranes and barriers. Passing of medicines through membranes. Absorption a distribution of medicines. Pharmacokinetics II. Biotransformation of medicines. Excretion. Studies of medicinal generics. Pharmacodynamics. Specific and non-specific effect. Receptors. Agonist, antagonist, parcial and inverse agonist. Pharmacology of CNS I. Pharmacology of CNS II. Pharmacology of PNS. Overview of medicines affecting respiratory system. Overview of medicines affecting gastrointestinal system. Overview of medicines affecting cardiovasculary system. Chemotherapeutics. Actual topic.
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Learning activities and teaching methods
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Dialogic (discussion, interview, brainstorming), Work with text (with textbook, with book), Projection
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Learning outcomes
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The aim of lectures is to explain the basics of general and special pharmacology.
Students are well oriented in basics of general and experimental pharmacology, they know therapeutic effects of selected drugs as well as mechanism of their action at the cellular level.
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Prerequisites
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There are not supposed any special skills or knowledge, only general competence of high school absolvent.
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Assessment methods and criteria
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Didactic test
Exam test
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Recommended literature
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Květina, Jaroslav. Základy farmakologie.. Brno: Veterinární a farmaceutická univerzita, 1999. ISBN 80-85114-44-5.
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Květina, Jaroslav. Základy farmakologie.. Brno: Veterinární a farmaceutická univerzita, 1999. ISBN 80-85114-45-3.
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Květina, Jaroslav. Základy farmakologie.. Brno: Veterinární a farmaceutická univerzita, 2000. ISBN 80-7305-391-8.
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Martínková, Jiřina. Farmakologie pro studenty zdravotnických oborů. Praha: Grada, 2007. ISBN 978-80-247-1356-4.
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