Clinical biochemistry is inter-discipline branch (definition, history, safety at work in laboratories of clinical biochemistry, operating sequences, biological materials). Influence on a sample preparation, summary of biochemical methods, results explication, analysis interference (extra-, intra-laboratory), laboratory results evaluation, analytical performance of method (inaccuracy, bias), clinical aspect (diagnostic sensitivity, specifity), reference values, external and internal control of quality (EQC,IQC). Laboratory information system and hospital information system. Mechanization and automatization in laboratories of clinical biochemistry, analyzer units. Internal environment of human: acid-base balance, water, electrolytes, microelements, theoretic introduction, electrolytes and microelements important for clinical practice, clinical implication (interpretation). Enzymes, theoretic introduction, general principles of clinical enzymology, enzymes in clinical practice, clinical implication (interpretation), diagnostic of myocardial infarction. Lipids: theoretic introduction (apoproteins, lipoproteins), lipids important for clinical practice, clinical implication (interpretation), atherosclerosis, independent risk factors of atherosclerosis, hyperlipidemias, general classification. Amino acids and proteins: theoretic introduction, important proteins in human plasma, clinical implication (interpretation), proteins of acute phase. Saccharids. General investigation of urine, urinary sediment, theoretic introduction, important compounds determined in human urine, clinical implication (interpretation), diabetes mellitus (diagnostic, compensation), proteinuria - summery. Metabolism of non-proteine nitric compounds. Blood pigments. Theoretic introduction (urea, uric acid), summary and importance of blood pigments, clinical implication (interpretation), creatinine, glomerular filtration, hyperbilirubinemia. Hormones, theoretic introduction (classification based on structure, effects, regulation of secretion, back-coupling), clinical implication (interpretation). Tumour markers. Metabolism of bone. Theoretic introduction (cancerogenesis, definition of tumour marker; structure and metabolism of bone), clinical implication (interpretation), osteoporosis. Concrements. Vitamins. Free radicals, antioxidants, theoretic introduction, clinical implication (interpretation). Function tests, kidneys, liver, gastro-intestinal tract, glycemic curve, function of glands with internal secretion. Therapeutic drug monitoring (TDM). Theoretic introduction, pharmacokinetic, reasons for TDM, general active substances, clinical implication (interpretation).
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