|
Lecturer(s)
|
-
Pouzar Miloslav, prof. Ing. Ph.D.
-
Šmíd Lenka, Mgr. Ph.D.
-
Trejtnar František, doc. PharmDr. CSc.
|
|
Course content
|
1. Opening lecture - interesting up-to day toxicological topic 2. Target organtoxicity I (nefro-,hepato-,hemato-,dermato and pulmotoxicity 3. Target organtoxicity II (neurotoxicity) 4. Mechanisms of toxicity on biochemical and cellular level 5. Interaction of toxic substance with organism I - absorption a distribution 6. Interaction of toxic substance with organism II - biotransformation, excretion, recept. 7. Factors affecting effects of toxic substances - dose-response curves 8. Experimental toxicology - modern methods of toxicological research 9. Toxicity of heavy metals 10. Toxicology of inorganic compounds of C, P, S a N 11. Carcinogens,mutagens and teratogens 12. Toxicology of drugs and drug precursors 13. Plant and animal toxins 14. Endocrine disruptors
|
|
Learning activities and teaching methods
|
|
Monologic (reading, lecture, briefing), Dialogic (discussion, interview, brainstorming), Work with text (with textbook, with book), Projection
|
|
Learning outcomes
|
The aim of lectures is to explain the basics of general and special toxicology with accent on problems occupational toxicology.
Students are well oriented in basics of general and experimental toxikology, they know toxic effects of elements and compounds selected as well as mechanisms of their toxicological activity and possibilities of toxicological risks reducing.
|
|
Prerequisites
|
Basic subject - there are not supposed any special skills or knowledge, only general competence of high school absolvent
|
|
Assessment methods and criteria
|
Oral examination, Written examination, Didactic test
Exam test 100 %
|
|
Recommended literature
|
-
Bajer T., Vyskočil A. Základy ekologie a toxikologie, Avicenum , Praha 1980.
-
Hodgson, Ernest . A Textbook of modern toxicology. Hoboken: Wiley-Interscience, 2004. ISBN 0-471-26508-X.
-
Jahodář L. Fytotoxikologie pro farmaceuty, Praha, Karolinum1995.
-
Kupec J. Toxikologie. VUT Zlín, 1999.
-
Linhart, Igor. Toxikologie : interakce škodlivých látek s živými organismy, jejich mechanismy, projevy a důsledky. Praha: Vysoká škola chemicko-technologická v Praze, 2012. ISBN 978-80-7080-806-1.
-
Matrka M., Rusek V. Průmyslová toxikologie. VŠCHT Pardubice, 1991.
-
Paleček J., Linhart I., Horák J. Toxikologie a bezpečnost práce v chemii. VŠCHT Praha, 1996.
-
Riedl O., Vondráček V. Klinická toxikologie. Avicenum, Praha, 1980. ISBN 08-075-80.
-
Rusek V. Základy toxikologie a úvod do problematiky hygieny a bezpečnosti práce v chemické laboratoři. Univerzita Pardubice, 2001.
-
Vopršalová M.,Žáčková P. Základy toxikologie, UK , Praha 1996.
|