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Lecturer(s)
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Kanďár Roman, prof. Mgr. Ph.D.
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Course content
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1. Metabolic pathways 2. Inherited errors of metabolism Examples of inherited disorders on metabolism of amino acids Enzymopaties, classification, mechanism of origin and phenotypic manifestations Biochemical screening and diagnosis of inherited errors of metabolism 3. Pathobiochemistry of carbohydrates Disorders of main metabolic pathways of carbohydrates Disorders of fructose and galactose metabolism Glycogeneses Regulation of blood glucose and its disorders Mucopolysaccharidoses-Glycoproteins and glycosylation, its disorders Diabetes mellitus-Molecular basis of diabetes Metabolic syndrome 4. Pathobiochemistry of lipids Lipoproteins, structure, metabolism Dyslipoproteinaemias Lipidoses Atherosclerosis 5.Pathobiochemistry of proteins and amino acids Aminoacidopathy, phenylketonuria, MSUD, homocystinuria Formation and metabolism of ammonia Disorders of ornithine cycle Intracellular degradation of proteins and its disorders 6. Pathobiochemistry of purines and pyrimidines Hyperuricaemia, gout Orotaciduria 7. Pathobiochemistry of porphyrines Porphyrias and hemoglobinopathies 8. Pathobiochemical changes in various types of icterus 9. Pathobiochemistry of coagulation and bleeding conditions 10. Pathobiochemistry of selected neurodegenerative diseases (Parkinson disease, multiple sclerosis, Alzheimer disease, Wilson disease, myasthemia gravis) 11. Mitochondiopathies disorders 12. Pathobiochemistry of hormones Hormonal signalization and its disorders Hypothalamic and pituitary hormones, adrenal steroid hormones, thyroid hormones, hormones of gonads 13. Biochemistry of tumors Physical and chemical carcinogens Biological factors in carcinogenesis Tumorigenic transformation Viral tumors Viral and cellular oncogenes Growth factors 14. Xenobiochemistry 15. Potential usage of genomics, transcriptomics and proteomics in medicine Seminar 1.Introduction, nomenclature, metabolism, the most important substances of metabolism Pyruvate dehydrogenase complex, citric acid cycle Respiratory chain before "Metabolic pathways" lecture 3. Carbohydrates: glycolysis, gluconeogenesis, pentose cycle before "Pathobiochemistry of carbohydrates" lecture 4. Lipids: fatty acids degradation (?-oxidation); fatty acids with even numbers of carbon atoms, fatty acids with odd numbers of carbon atoms, branched-chain fatty acids; fatty acids synthesis + chain extension of fatty acids (elongase) and the insertion of double bonds in the fatty acid chain (desaturase Lipoprotein metabolism Synthesis and degradation of cholesterol before "Pathobiochemistry of lipids" lecture 5. Amino acids degradation (general) + degradation of nitrogen; ornithine (urea) cycle Amino acids degradation: carbon skeleton before "Pathobiochemistry of proteins and amino acids" lecture 6. Synthesis and degradation of purine and pyrimidine nucleotides before "Pathobiochemistry of purines and pyrimidines" lecture 7. Synthesis and degradation of hem before "Pathobiochemistry of porphyrines" lecture
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Learning activities and teaching methods
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Monologic (reading, lecture, briefing), Dialogic (discussion, interview, brainstorming)
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- 60 hours per semester
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Learning outcomes
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The discipline aims to explain diseases at the molecular level.
Graduate is able to take one's bearing in problems of pathological processes of human organism.
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Prerequisites
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C627 - General Biochemistry C631 - Clinical Biochemistry C633 - Physiology and Pathophysiology
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Assessment methods and criteria
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Oral examination
oral examination
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Recommended literature
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Donald Voet, Judith G. Voet. Biochemie. Victoria Publishing, 1995. ISBN 80-85605-44-9.
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Jan Musil, Olga Nováková. Biochemie v obrazech a schématech. Avicenum Praha, 1990. ISBN 08-109-89.
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Jaroslav Racek. Klinická biochemie. Galén, 2006. ISBN 80-7262-324-9.
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Marta Kalousková. Patobiochemie ve schématech. Grada Praha, 2005. ISBN 80-247-1522-8.
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Miroslav Ledvina, Roman Kanďár. Přehled patobiochemie. Univerzita Pardubice, 2001. ISBN 80-7194-399-1.
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Peter Karlson, Wolfgang Gerok, Werner Gross. Pathobiochemie. Academia Praha, 1987. ISBN 21-041-87.
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Stanislav Štípek. Antioxidanty a volné radikály ve zdraví a nemoci. Grada Praha, 2000. ISBN 80-7169-704-4.
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Tomáš Zima. Laboratorní diagnostika. Galén, 2007. ISBN 978-80-7262-372-3.
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