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Lecturer(s)
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Štěpánková Šárka, Mgr. Ph.D.
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Kanďár Roman, prof. Mgr. Ph.D.
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Course content
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Basic types of cell-to-cell communication. Signaling molecule types. Membrane-bound receptors. Enzyme-coupled receptors. Tyrosine-specific kinases, the MAP kinase cascade. Ion channel coupled receptors. G-protein coupled receptors. The second messenger. Guanylate cyclase and NO-synthase signaling pathways. Intracellular receptors. Mechanism of steroid and thyroid hormone action. The GTPase superfamily and their cellular functions.
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Learning activities and teaching methods
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Monologic (reading, lecture, briefing)
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Learning outcomes
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The subject introduces the student to knowledge in the field of cell signaling. It builds on the knowledge of biochemistry.
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Prerequisites
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unspecified
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Assessment methods and criteria
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Oral examination
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Recommended literature
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Gerhard Krauss. Biochemistry of Signal Transduction and Regulation. Bayreuth: Germany, 2014. ISBN 9783527333660.
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Ijsbrand Kramer. Signal Transduction. London: United Kingdom, 2015. ISBN 9780123948038.
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John T Hancock. Cell Signalling. Glasgow: Great Britain, 2017. ISBN 9780199658480.
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