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Lecturer(s)
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Komersová Alena, doc. Ing. Ph.D.
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Course content
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unspecified
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Learning activities and teaching methods
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Monologic (reading, lecture, briefing), Dialogic (discussion, interview, brainstorming), Work with text (with textbook, with book)
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Learning outcomes
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The subject deepens the knowledge int he field of mathematical description of pharmacokinetic and pharmacodynamic processes and shows the possibilities of using of mathematical models and suitable PC programs to predict the drug concentration in vivo and to individualize the drug dosing. Particularly, the comparmental procedures of the pharmacokinetic analysis, non-compartmental methods for estimating of pharmacokinetic parameters, factors determinig the response of organism to the drug, and correlation in vitro/in vivo are discussed. Various types of an empirical, semiempirical pharmacokinetic models, deterministic ans stochastic compartmental models are discussed in more detail.
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Prerequisites
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unspecified
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Assessment methods and criteria
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Oral examination, Home assignment evaluation
Oral exam and defense of a seminar work focusing on the area of student's interest related to the topic of the dissertation work.
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Recommended literature
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Bonate, Peter L. Pharmacokinetic-pharmacodynamic modeling and simulation. New York: Springer Science+Business Media, 2011. ISBN 978-1-4419-9484-4.
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Hedaya M.A.:. Basic Pharmacokinetics. CRC Press, Taylor & Francis Group, Boca Raton, USA,, 2007.
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Macheras P., Iliadis A. Modeling in Biopharmaceutics, Pharmacokinetics, and Pharmacodynamics. New York: Springer Science+Business Media, 2006.
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