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Lecturer(s)
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Šklubalová Zdeňka, doc. PharmDr. PhD.
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Mužíková Jitka, PharmDr. Ph.D.
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Course content
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Modern test methods used in Pharmaceutical Technology include evaluation of solid phase properties, characterization of crystallinity and / or amorphous state (X-ray powder diffraction, thermal analysis), surface properties (wettability, porosity and pore distribution, water sorption / desorption, surface area), and particle size (laser diffraction, optical microscopy, aerodynamic determination). The subject is supplemented by specific pharmaceutical methods for excipients (e.g. penetrometry, density of solids, sieve analysis, powder flowability, powder fineness, specific surface) and for final preparations (dose uniformity, tablet strength and friability, disintegration of tablets or suppositories, dissolution tsting.)
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Learning activities and teaching methods
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Dialogic (discussion, interview, brainstorming), Work with text (with textbook, with book)
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Learning outcomes
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Learning outcomes of the course are the pharmacopoeial technological and selected physical and physico-chemical methods of evaluation of excipients, pharmaceutical products and dosage forms. Attention is also paid to the other methods not specified in Pharmacopoeia but used to extend evaluation.
finished master degree
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Prerequisites
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basic knowledge of physical and analytical chemistry
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Assessment methods and criteria
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Oral examination
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Recommended literature
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allen L.V. The Science and Practise in Pharmacy. 2011. ISBN 978-0857110626.
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Česko. Český lékopis 2009 (ČL 2009). Praha: Grada, 2009. ISBN 978-80-247-2994-7.
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storey R.A. Solid State Characterizatin of Pharmaceuticals. 2011. ISBN 978-1405134941.
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