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Lecturer(s)
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Doležal Jiří, doc. MUDr. Ph.D.
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Course content
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Thyroid scintigraphy. Thyroid accumulation test. Scintigraphy of the parathyroid glands - subtraction, washout. Radionuclide methods in pneumology. Ventilation scintigraphy of the lungs - radiopharmaceuticals. Dynamic and static ventilation scintigraphy. Indications. Perfusion scintigraphy of the lungs - indications, radiopharmaceuticals, performance, evaluation. Skeletal and bone marrow scintigraphy. Planar skeletal scintigraphy. 3-phase skeletal scintigraphy. SPECT/CT of the spine. Radionuclide brain scans. Perfusion scintigraphy of the brain - SPECT. Radionuclide cysternography. SPECT of the brain with 123I-Ioflupane in m. Parkinson. PET/CT of brain metabolism with 18F-FDG. PET/CT of brain with 18F-FLT and 18F-FMISO amino acids. Oncological diagnostics by nuclear medicine methods. Scintigraphy with gallium 67 - indications, performance, evaluation. Scintigraphy and PET/CT of estrogen receptors. PET/CT with 18F-NaF. Scintigraphy of tumors with 99mTc-MIBI. Sentinel lymph node scintigraphy. Diagnosis of hormonally active tumors with somatostatin receptors. PET/CT of tumors. Radionuclide examination of salivary glands, indications, radiopharmaceuticals, performance. Dynamic esophageal scintigraphy and transit time through the esophagus. Examination of gastric evacuation. Detection of Meckel's diverticulum. Detection of GIT bleeding using labelled autologous erythrocytes. Diagnosis of inflammation (labelled autologous leukocytes or granulocytes, 67Ga citrate, 18F-FDG). Equilibrium gated ventriculography - radiopharmaceuticals, indications, performance, evaluation. Detection of cardiac shunts by first pass analysis. Myocardial perfusion SPECT. Stress tests (physical stress, pharmacological stress). Demonstration of viable myocardium. Open beam therapy. Therapy of thyroid cancer and thyrotoxicosis with iodine 131. Therapy of painful bone metastases with radionuclides. Detection of gastrointestinal bleeding by nuclear medicine methods. Perfusion brain scintigraphy - SPECT. PET/CT of the brain - 18F-FDG, 18F-FLT. Radionuclide cisternography. Radionuclide ventriculography. Myocardial perfusion scintigraphy. Scintigraphy and PET/CT of estrogen receptors. Diagnosis of inflammation by labeled leukocytes, granulocytes, 67 gallium, 18F-FDG PET. Scintigraphy of tumors with 67 gallium. Scintigraphy with somatostatin analogues. Whole-body scintigraphy of tumors after 131I and 99mTc-MIBI treatment. Mamoscintigraphy. 18F-FDG, 18F-FLT PET/CT I tumor detection. 18F-FDG tumor detection, 18F-FLT PET/CT II. Radionuclide therapy.
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Learning activities and teaching methods
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Monologic (reading, lecture, briefing), Demonstration, Skills training
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Learning outcomes
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The aim of the subject of nuclear medicine is to acquaint students with history and development of radionuclide functional and imaging methods, and their position within current diagnostic and therapeutic algorithm. This subject discusses in detail individual radionuclide imaging methods, health state and pathological findings in planar and dynamic scintigraphy, single photon emission computed tomography (SPECT, SPECT/CT) and positron emission computed tomography (PET, PET/CT) according to particular organ systems. The subject provides practical knowledge of operating devices used in nuclear medicine, e.g. scintillation detector, scintillation gamma camera, SPECT, SPECT/CT, PET, PET/CT. The subject also focuses on use of therapeutic radionuclides in medicine (treatment of painful bone metastasis, thyroid cancer, hyperthyroidism, endocrine ophthalmopathy, etc.). Last but not least, the subject deals with effects of ionizing radiation on organism and protection against it. Students will master the subject matter in the extent outlined by the syllabus.
Student will gain competence to independently perform radionuclide examining and treatment methods, operate a gamma camera SPECT, SPECT/CT, PET/CT, provide treatment by radionuclides, and dispose of radioactive waste.
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Prerequisites
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unspecified
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Assessment methods and criteria
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Oral examination
Completion of an oral examination. 80% attendance at seminars.
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Recommended literature
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APPELBAUM D. et al. Nuclear Medicine. USA, New York: Thieme Medical Publisher, 2012.
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BENNETT P., OZA U. D. et al. Diagnostic Imaging: Nuclear Medicine. Philadelphia, USA: Elsevir, 2016. ISBN 978-0-323-37753-9.
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BLODGETT TM. et al. Speciality Imaging - PET/CT. USA, Salt Like City: Amirsys, 2009.
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FANTI S. et al. Atlas of SPECT-CT. Berlin: Springer, 2011.
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CHERRI SROV et al. Physics in Nuclear Medicine. USA, Philadelphia: Elsevier Saunders, 2012.
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CHRISTIAN PE. et al. Nuclear Medicine and PET/CT. USA, Philadelphia: Elsevier Mosby, 2011.
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KAMINEK, M.; LANG, O.; TROJANOVÁ, H. Nukleární kardiologie. Praha: Galen, 2008. ISBN 978-80-7262-481-2.
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Koranda, Pavel. Nukleární medicína. Olomouc: Univerzita Palackého, 2014. ISBN 978-80-244-4031-6.
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LIN CL. et al. PET and PET/CT. USA, New York: Thieme Medical Publisher, 2009.
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MORTON K. A., CLARK P. B. et al. Diagnostc Imaging: Nuclear Medicine. Salt Lake City, Utah: Amirsys, 2007. ISBN 978-1-416-03339-4.
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VOTRUBOVÁ J. et al. Klinické PET a PET/CT. Praha: Galen, 2009.
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ZIESSMANN H. A., O'MALLEY et al. Nuclear medicine. Philadelphia, USA: Elsevier/Saunders, 2014. ISBN 978-0-323-08299-0.
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