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Lecturer(s)
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Vinklárek Jaromír, prof. Ing. Dr.
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Course content
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introduction to the subject: task formulation, literature chemistry of group 1 elements - alkali metals, biological function, sodium-potassium pump. chemistry of elements of 2 groups - alkaline earth metals, biological function x toxicity, calcium deposition in bones, chlorophyll (Mg) chemistry of transition metal elements, biological function, metalloenzymes, glucose tolerance factor (Cr), superoxide dismutase (Mn), vitamin B12(Co) hemoglobin and cytochromes (Fe), hemocyanin (Cu), cis-platinum, history, mechanism of action, next-generation platinum cytostatics non-platinum antitumor drugs, other possibilities of using transition metals as metallotherapeutics. biological function of Zn (enzymatic cycles) x toxicity of metals (Cd, Hg) non-metals, hydrogen, hydrogen bond, theory of acids and bases. chemistry of elements of 14 groups, biopolymers (Si), toxicity (Ge, Sn, Pb) chemistry of group 15 elements, biological nitrogen fixation, toxicity (As, Sb, Bi) chemistry of elements of 16 groups, biological function x toxicity, ozone, binding possibilities of sulfur in biological structures chemistry of elements of 17 groups, biological function, oxygenic and hydrohalic acids, structure x acidity
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Learning activities and teaching methods
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Monologic (reading, lecture, briefing), Dialogic (discussion, interview, brainstorming)
- Preparation for a final test
- 10 hours per semester
- Participation in classes
- 30 hours per semester
- Home preparation for classes
- 10 hours per semester
- Data/material collection
- 10 hours per semester
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Learning outcomes
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The aim of the subject is to familiarize students with the chemistry and properties of selected elements and compounds with regard to their function in biological systems or their toxicity.
Students will acquire knowledge related to the biological function or potential toxicity of selected elements.
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Prerequisites
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Fundamental knowledge of general and inorganic chemistry, organic chemistry, biology and biochemistry.
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Assessment methods and criteria
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Oral examination, Written examination
Continuous monitoring of studies during the semester is carried out in the form of 2 written papers, the results of which are included in the overall classification.m.
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Recommended literature
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Bertiny I., Gray B.H., Lippard S.J.,Valentine J.S. Bioinorganic Chemistry. University science Books: California., 1994.
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C.E. Housecroft. Anorganická chemie. Praha, 2014. ISBN 978-80-7080-872-6.
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Deutche Forschungemeinschaft. Bioinorganic Chemistry. WILEY-VCH: Weinheim., 1997.
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Jacimirskij K.B. Einfűhrung in die bioanorganische Chemie. Berlin: Akademie-Verlag, 1980.
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Robert R. Crichton. Biological inorganic chemistry. 2007. ISBN 978-0-444-52740-0.
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