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Lecturer(s)
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Matvieiev Oleksandr, Ph.D.
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Pouzar Miloslav, prof. Ing. Ph.D.
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Trejtnar František, doc. PharmDr. CSc.
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Course content
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1. Toxicokinetics I - absorption and distribution of toxic substances in the human body 2. Toxicokinetics II - biotransformation and excretion of toxic substances in the human body 3. Toxicology at the organ level I (hemato-, hepato-, nephro-, pulmo- and dermatotoxic substances) 4. Toxicology at the organ level II (neurotoxic substances) 5. Biochemical mechanisms of toxic effects I (cell cycle and oxidative stress) 6. Biochemical mechanisms of toxic effects II (genotoxic and carcinogenic substances) 7. Biochemical mechanisms of toxic effects III (endocrine disruptors and teratogenic substances) 8. Biochemical mechanisms of toxic effects IV (immunotoxic substances, allergens) 9. Adaptive response and the effect of the aging on the effects of toxic substances 10. Alcohol and caffeine - example of interactions of toxic substances in the body 11. Nanopharmaceuticals - targeted drug transport and associated toxicological risks 12. Nitrosamines in pharmaceuticals - examples of degradation of pharmacologically active substances into toxic products 13. Preclinical drug research, pharmacovigilance, basics of epidemiological research on the effects of substances
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Learning activities and teaching methods
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Monologic (reading, lecture, briefing), Dialogic (discussion, interview, brainstorming), Work with text (with textbook, with book), Projection
- Participation in classes
- 26 hours per semester
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Learning outcomes
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The aim of the lectures is to explain the students the issue of the interaction of a toxic substances with an organism, with the general mechanisms of a toxic effect at the biochemical, organ and systemic level, as well as with the effects of selected groups of natural toxins and pharmaceuticals.
After completing the course, the student is oriented in the principles of general toxicology with an emphasis on the biochemical mechanisms of action of selected groups of substances, understands the relationship between the dose and response of substances, the relationship between the pharmacological and toxic effects of substances, and is oriented in the basic methods toxikological methodology
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Prerequisites
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Basic subject - there are not supposed any special skills or knowledge, only general competence of high school absolvent
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Assessment methods and criteria
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Oral examination, Written examination, Didactic test
Semestral tests for more than 50%, or exam test for 80% Oral exam
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Recommended literature
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Bajer T., Vyskočil A. Základy ekologie a toxikologie, Avicenum , Praha 1980.
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Hodgson, Ernest . A Textbook of modern toxicology. Hoboken: Wiley-Interscience, 2004. ISBN 0-471-26508-X.
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Jahodář L. Fytotoxikologie pro farmaceuty, Praha, Karolinum1995.
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Klaassen C.D. Casarett & Doull's Toxicology: The Basic Science of Poisons (9th Edition). McGraw Hill / Medical, 2018. ISBN 978-1259863745.
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Kupec J. Toxikologie. Zlín: VUT, 1999.
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Linhart, Igor. Toxikologie : interakce škodlivých látek s živými organismy, jejich mechanismy, projevy a důsledky (3. upravené a rozšířené vydání). Praha: Vysoká škola chemicko-technologická v Praze, 2022. ISBN 978-80-7592-103-1.
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Linhart, Igor. Toxikologie : interakce škodlivých látek s živými organismy, jejich mechanismy, projevy a důsledky. Praha: Vysoká škola chemicko-technologická v Praze, 2012. ISBN 978-80-7080-806-1.
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Matrka M., Rusek V. Průmyslová toxikologie. Pardubice: VŠCHT, 1991.
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Paleček J., Linhart I., Horák J. Toxikologie a bezpečnost práce v chemii. Praha: VŠCHT, 1996.
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Pouzar M. Kalich hořkosti. Akademické nakladatelství CERM, 2013. ISBN 978-80-7204-851-9.
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Riedl O., Vondráček V. Klinická toxikologie. Praha: Avicenum, 1980. ISBN 08-075-80.
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Rusek V. Základy toxikologie a úvod do problematiky hygieny a bezpečnosti práce v chemické laboratoři. Pardubice: Univerzita Pardubice, 2001.
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Vopršalová M.,Žáčková P. Základy toxikologie, UK , Praha 1996.
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