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Lecturer(s)
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Sedlák Miloš, prof. Ing. DrSc.
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Halama Aleš, Ing. Dr.
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Imramovský Aleš, prof. Ing. Ph.D.
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Course content
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Anesthetic agents Muscle relaxants Sedative/hypnotics agents Anticonvulsants, antiparkinsonians, antihistamines Psychotropic agents (antidepressants, antipsychotics, anxiolytics, CNS stimulants, nootropics) Analgetic agents and antipyretics Antispasmodics Cardiotonics, antianginals, antiarhythmics, vasodilators, -adrenergic agents, anticoagulants, Antihypertensive agents Antiinflammatory agents Antineoplastic agents Antibacterial agents (sulphonamides, antimalaricals, tuberculostatics) Diuretics Antiseptics/disinfectants Anthelmintics
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Learning activities and teaching methods
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Monologic (reading, lecture, briefing)
- unspecified
- 56 hours per semester
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Learning outcomes
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The student will meet the production of "active substances", used in pharmaceutical industry, which cover a very wide range of structural types both carbocyclic and heterocyclic substances. He will recognize a broad selection of organic reactions which were chosen to illustrate the strategy and the organic transformations that were used to prepare the various structural classes used as medical drugs.
The student will be informed on active substances used in pharmacy. He will also know about synthetic procedures used for synthesis of various structural classes of drugs.
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Prerequisites
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The course is designed for students of Master's degree. For successful completing the course is to be familiar with the content of the following subjects: UOCHT/C008 Organic chemistry UOCHT/C511 Basic principles of organic synthesis UOCHT/C318 Bioorganic chemistry UOCHT/C059 Organic synthesis UECHI/C188 Equipment and processes in organic technology UOCHT/C564 Intermediates of organic processes
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Assessment methods and criteria
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Oral examination, Written examination
Understanding and active knowledge of Basic organic synthesis.
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Recommended literature
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Hampl, F. Farmakochemie. Praha, 2015. ISBN 978-80-7080-875-7.
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Johnson, D. The Art of Drug Synthesis. 2007. ISBN 978-0-471-75215-8.
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Kuchař, M. Výzkum a vývoj léčiv. Praha, 2008.
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Lednicer D. Strategies for Organic Drug Synthesis and Design. ISBN 9780470190395.
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Lednicer D. Strategies for Organic Drug Synthesis and Design. 1998. ISBN 9780470190395.
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Vardanyan, R. Synthesis of Essential Drugs. Elsevier Science: Tucson, USA. ISBN 978-0-444-52166-8.
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Vardanyan, R. Synthesis of Essential Drugs. Elsevier Science: Tucson, USA, 2006. ISBN 978-0-444-52166-8.
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Wilson C. O., Gisvold O., Doerge R. F. Textbook of Organic Medicinal and Pharmaceutical Chemistry, 1991 J. B. Lippincott Comp., Philadelphia, Toronto..
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