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Lecturer(s)
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Pejchal Vladimír, doc. Ing. Ph.D.
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Course content
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Azeotropic distillation; sublimation: chloracetamide. Preparation of sample for elemental analysis. Fractional recrystallization: 3-nitrophthalic acid. Chromatographic check of fractional recrystallization. Phase-transfer catalysis: 7,7-dichlorobicyclo[4,1,0]heptane. Preparation of sample for NMR spectroscopy. Thermal decomposition: preparation of 4-fluorobenzene. Preparation of sample for IR spectroscopical measurement. Catalytic hydrogenation: preparation of stearic acid. Vacuum distillation: 4-nitrobenzoyl chloride. 4-Nitrobenzaldehyde; preparation of derivatives. Butylamine Salicylaldehyde. Salazine. 2-Phenylthiazole picrate. Luminol. Drying and deoxygenation of diethylether resp. THF (working under inert condition).
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Learning activities and teaching methods
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Monologic (reading, lecture, briefing), Demonstration, Skills training, Laboratory work
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Learning outcomes
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The course develops knowledge and practical skills of organic syntheses from previous laboratory courses with the use of more sophisticated laboratory techniques (vacuum distillation, heterogeneous reaction, handling Pt catalyst etc.). The course involves more complex multistep syntheses and verification of structure (and purity) of product by means of separation and spectral methods such as HPLC, elemental analysis, NMR, IR.
The students will obtain the new knowledge of laboratory techniques especially from organic synthesis.
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Prerequisites
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The students should be able to do basic laboratory techniques independently for passing of the course unit
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Assessment methods and criteria
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Home assignment evaluation, Work-related product analysis, Creative work analysis
Semestral work
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Recommended literature
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KVÍČALA J.:. Laboratorní technika organické chemie, VŠCHT Praha, 1998, [ISBN-80-7080-322-2]..
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MACHÁČEK V. A KOL:. Návody pro laboratorní cvičení z organické chemie, Univerzita Pardubice, 1999, [ISBN-80-7194-646-X]..
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SEDLÁK M., HANUSEK J.:. Laboratorní cvičení z organické syntézy, (dokument v elektronické podobě na stag.upce.cz) Univerzita Pardubice 2003..
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VEČEŘA M., GASPARIČ J.:. Důkaz a identifikace organických látek, SNTL, 1973. [ISBN-04-613-73]..
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VEČEŘA M., PANCHARTEK J.:. Laboratorní příručka organické chemie, SNTL Praha, 1987, [ISBN-04-615-87]..
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