|
Lecturer(s)
|
-
Slováková Marcela, doc. Mgr. Ph.D.
-
Kroutilová Helena, Ing.
-
Bílková Zuzana, prof. RNDr. Ph.D.
-
Erbenová Olga, MUDr.
-
Součková Jindra, Ing.
-
Andrejsová Lenka, pplk. Mgr. Ph.D.
-
Roušar Tomáš, prof. RNDr. Ph.D.
-
Krykorková Hana, Mgr.
|
|
Course content
|
Clinical Hematology section: Week 1: Anemia: classification of anemias - morphological, etiopathogenetic. Anemia from a disorder of erythrocyte formation: anemia from a disorder of heme formation. Anemia from globin synthesis disorder, DNA. 2nd week: Megaloblastic, aplastic (primary marrow depression) and dyserythropoietic anemia, Anemia from increased ERY loss: corpuscular hemolytic anemia, extracorpuscular hemolytic anemia, acute posthemorrhagic anemia. Week 3: Leukopenia and leukocytosis: definition, classification, diagnosis and differential diagnosis. Disorders of the leukocyte system ? quantitative, qualitative (functional, morphological). 4th week: Hematological laboratory tests - overview, principles of methods, interpretation of results. Week 5: Disorders of hemostasis. Platelet disorders ? quantitative, qualitative, substitution treatment. Immune thrombocytopenia - primary, secondary. Disorders of blood coagulation due to plasmatic causes - congenital, acquired, thrombotic. Thrombophilic conditions in pregnancy. Antithrombotic treatment. Haemocoagulation examination - an overview. Week 6: Classification of hemato-oncological diseases: myelodysplastic syndrome, acute myeloid leukemia, acute lymphoblastic leukemia, chronic lymphocytic leukemia. Myeloproliferative diseases. Non-Hodgkin's malignant lymphomas, Hodgkin's disease. Plasma cell myeloma. Monoclonal gammopathy. Multiple myeloma. Week 7: Principles of supportive treatment in hematology. Prevention of septic conditions after splenectomy (OPSI). Secondary medullary attenuations. Febrile neutropenia. section Transfusiology: 8th week: Introduction to the field of transfusion medicine. Blood group systems (KSS) of erythrocytes, leukocytes, thrombocytes. Meaning of KSS in cl. practice (transfusion, transplantation, pregnancy). Blood donation and legislation. Register of blood donors, donor selection. Pre-transfusion examination. Collection of blood, blood components, autotransfusion, separators. Blood banks. 9th week: Immunohematological examination during pregnancy and after delivery, hemolytic disease of the newborn (HON) and acquired hemolytic anemia, AB0 incompatibility, Rh incompatibility, in other erythrocyte systems. AIHA. 10th week: Post-transfusion reactions, causes, transfusion-transmitted infections, laboratory diagnostics (direct, indirect). Methods of preventing the transmission of infectious diseases. 11th week: Transfusion preparations and blood derivatives. Production and storage of transfusion preparations and plasma for industrial fractionation, deleukotization. Cryopreservation. Laboratory examination of transfusion preparations and plasma for fractionation, hemovigilance 12th week: Principles of purposeful hemotherapy, indications of transfusion preparations, blood derivatives. Quality control of transfusion preparations and plasma for fractionation, related documents of the Czech Republic and the EU. Diagnostic sera, specifications and quality controls. Good manufacturing practice. System of internal and external quality controls. Week 13: Transplantation of stem cells. Bone marrow donor registries. Stem cells in tumor therapy, in regenerative medicine. Flow cytometry and its use in hematology and transfusion medicine.
|
|
Learning activities and teaching methods
|
|
unspecified, Monologic (reading, lecture, briefing), Dialogic (discussion, interview, brainstorming), Work with text (with textbook, with book)
|
|
Learning outcomes
|
The course closely follows the course Fundamentals of Hematology and provides an overview of the most common pathophysiological entities in clinical practice, including disorders of hemostasis. Emphasis is placed on the pathophysiological conditions associated with blood cell diseases: i.e. hematopoietic blood cell diseases, disorders of erythrocytes and platelets, disorders of the white blood cell, including hematopoietic tumors. The subject provides information on the clinical significance of individual examinations and how to interpret the results. In the transfusion section, the emphasis is placed on knowledge of transfusion preparations (types, biological effects, correct manufacturing practice), transfusion techniques, prevention and diagnosis of post-transfusion complications, blood derivatives, indications for the administration of transfusion preparations and therapeutic hemapheresis. Seminars are used to practice the discussed topics with specific case reports, an overview of indicated laboratory examinations and evaluation of their results in a clinical context.
|
|
Prerequisites
|
unspecified
KBBV/C463
|
|
Assessment methods and criteria
|
Oral examination, Written examination, Self project defence
Lectures in monologic form. Mandatory attendance at seminars. As part of the seminar, the obligation to prepare a presentation on a given topic. The exam takes the form of a written test with verbal answers and test questions. The condition for successful completion of the course: 1) obtaining at least 60% of the total number of points from the test, 2) an oral exam.
|
|
Recommended literature
|
-
Doporučení ČHS ČLS JEP.
-
Faber E. et al. Základy hematologické diagnostiky, druhé přepracované vydání. Mladá fronta.s.: Praha 2015.
-
Indrák K. Hematologie a transfuzní lékařství. Praha, 2014. ISBN 978-80-7387-722-4.
-
Pecka, M. Přehled laboratorní hematologie. Díl I.: Červená krevní řada: Krvetvorba. Praha, Galén, 1995.
-
Pecka, M. Přehled laboratorní hematologie. Díl 2., Bílá krevní řada, Krevní destička. Praha, Galén, 1997.
-
Pecka, Miroslav. Laboratorní hematologie v přehledu : buňka a krvetvorba. Český Těšín: Finidir, 2002. ISBN 80-86682-01-3.
-
Penka, M. Slavíčková E. Hematologie. Praha: Grada, 2011.
-
Penka, M., Tesařová E. Hematologie a transfuzní lékařství I, II. Grada: Praha 2012.
-
Řeháček V., Masopust J. a kol. Transfuzní lékařství. Grada Praha 2013.
-
Vydra J., Novák J, Lauermanová M. a kol. Hematologie v kostce, druhé přepracované vydání. Mladá fronta a.s.: Praha 2019.
|